Nadezhda Karyazina was born in Moscow in 1986, and from 2003 to 2008 was trained at the Russian Academy of the Theatrical Arts in Moscow, at the faculty of the musical theater.

After she graduated from the Academy she was admitted to the Galina Vishnevskaya Opera Center, where among others she performed the roles of Laura in Tchaikovsky's Iolantha, Contessa di Ceprano in Verdi's Rigoletto, Dunyasha in Rimsky-Korsakov's The Tsar's Bride, Siebel in Gounod's Faust and Olga in Tchaikovsky's Eugene Onegin. 

Nadezhda Karyazina is a third place winner of Placido Domingo's annual opera competition Operalia (Beijing, 2012). Other prizes Nadezhda has won include a Diploma at the Russian Theatrical Competition 'Capital Renaissance' (2008), and she has given concerts in Italy, Germany, Poland and Russia. 

Since 2010 she has been a member of the Young Artist Program of the Bolshoi Theatre of Russia, where she has taken part in master-classes with Gloria Guida Borelli, Laura Claycomb, Elena Obraztsova, Eugeny Nesterenko, Luba Orfenova, Diane Zola, Richard Bado and Ann Hallenberg among others. 

She has performed the roles of Marquise Melibea in scenes from Il viaggio a Reims by Rossini at the Tchaikovsky Concert Hall in Moscow with the chamber orchestra 'Moscow Soloists' under Yuri Bashmet, and her debut at the Bolshoi was as Petrovna in Rimsky-Korsakov's The Tsar's Bride conducted by Vasily Sinaisky.

In March 2011 she also sang the part of mezzo-soprano in Mozart's Requiem at the Novosibirsk State Academic Opera and Ballet Theatre.

Among her future engagements are Olga (Eugene Onegin), Lel (The Snow Maiden), Soneyetka (Lady Macbeth of Mtsensk) and Princess Clarice (The love of three Oranges) at the Bolshoi Theatre.